Use of Intravenous Fat Emulsion in the Emergency Department for Cardiovascular Collapse in the Poisoned Patient

The successful use of intravenous fat emulsion (IFE) for the adverse effects associated with local anesthetics has led to its consideration as an effective antidote for multiple xenobiotics/substances (1, 2, 3, 4, 5, 6) . Similar to most toxicology research, the evidence is completely reliant on animal experiments and human case reports. In addition to lack of definitive efficacy, there is the question of safety. Fat emboli, acute lung injury, lipemia, pancreatitis, interference with standard medication therapies, and hypersensitivity are all concerns of unproven clinical significance (7, 8). In addition, IFE has been shown to result in analytical interference with certain laboratory assays (9). However, our goal was to supply the emergency physician a practical guideline for the use of IFE in critically poisoned patients.

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