Does Early Goal-Directed Therapy Decrease Mortality Compared with Standard Care in Patients with Septic Shock?

Reviewed and approved by the AAEM Board of Directors (2/17/2016)

Answer: No. However, standard care has significantly improved since the publication of the original EGDT trial. Early recognition of sepsis, prompt administration of appropriate antimicrobial therapy, urgent source control, intravenous fluid, and maintenance of adequate mean arterial pressure are critical interventions in the care of patients with septic shock. Routine central venous pressure or central venous oxygenation measurements are not required.

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