Reviewed and approved by the AAEM Board of Directors 2/14/2010.
- Define the Issue and State the Question
- A. Topic Area: Sepsis
- B. General Issue: Steroid administration in septic shock
- C. Clinical Question: Do steroids administered in the emergency room improve mortality or shock reversal in patients with septic shock?
- D. Executive Summary:
- Answer: Overall Benefit: Yes. Although the literature is heterogeneous, underlying themes remain in distinct favor of steroid administration in patients with refractory septic shock. (Level of Recommendation: B1)
28-Day Mortality: No (Level of Recommendation: C)
Shock Reversal: Yes (Level of Recommendation: A)